For those of you who haven't updated, WordPress 2.6 is now out and you should update. I have been running it a little bit and have not seen any problems.
The one function I do like is the plug-in management. The previous versions put all the plug-ins together, whether they were active or not. WordPress 2.6 separates the active plugins from the disabled ones. It is nice.
Give it a try! At least do it for all of us who are on the Internet and protect us from viruses and other bad things.